| Name: |
Synthetic and Separating Experiments on the Advanced Organic and Polymeric Chemistry |
| Catalog Number: |
419003Y |
Hours/Credits: |
70/2 |
| Prerequisite(s): |
|
Organic Synthesis or Synthetic polymer chemistry, Analytic Chemistry |
| Course Description: |
|
The course is related professional (organic synthesis, drug synthesis, materials, biochemistry and chemical biology) of synthetic chemistry and chemical separation (more professional and herbs separation, separation of natural medicine, bio-separation) and related professional experiments basic course. The chemistry experiment is the basic means of chemical scientific research and experimental data is the main basis of chemical theory. Strengthen the experimental teaching to enhance students' ability to strengthen the disciplines of the important measures of graduate quality education in chemistry experiments.
The principle of combining the experimental course in line with the theoretical and experimental, through the literature search, combined with already studied the chemical theory of knowledge, students in groups to carry out the preparation of experimental apparatus, the reaction of the implementation process tracking, and timely to terminate the reaction and purification processing, product structure identification, and independently complete the test report. This course focuses on students of experimental thinking, experimental design, hands-on, independent analysis of problems and to solve problems independently a wide range of ability. |
| Course Content: |
|
A Purification and separation
1) Introduction of the basic principles and methods of type:
Practicing the separation by using the natural products or synthesized new compounds.According to the basic physical properties ( liquid or solid, polarity, solubility, UV absorption and others) of to determine and select the following separation and purification methods: extraction, recrystallization, sublimation, solvent precipitation method, single crystal growing, (reduced pressure, water vapor) distillation, chromatographic separation
2) Solvents selection and optimization experiments of separation by using thin-layer chromatography (TLC)
TLC is the one of the most simple and fastest separation methods, but how to choose the solvents should be a very strong experienced work. Single solvent, or mixed solvents, polar solvents, non-polar solvents are chosen based on the polarity of the specified compounds.
3) Extraction and separation of spinach pigment
Experimental purposes: A better understanding the separation of natural substances extraction and purification methods by extracting and purifying the green plant pigments; A better understanding of the principle of chromatographic separation of trace organic materials by using the column chromatography and thin layer chromatography,
B The synthetic experimental theory and experimental preparation
1) The theoretical preparation of the synthetic chemistry
2) Efficient literature review
3) The standardization of the experimental records reports
4) The basic principles on the reaction design, predicting reaction, the determination on the synthetic route.
5) Quality of the reactants and reaction solvents, How to improve chemicals purities.
6) Bioactive analysis for chemicals, environmental pollution and green chemistry
7) Optimization process on the chemical reaction conditions: temperature, time, solvent and the amounts.
C The Contents on the experimental syntheses.
General purpose and requirements:
1) Practicing synthesized reaction, learning and mastering the experimental principles and methods: correct feed process, the implementation of the reaction under various conditions.
2) Proficiently master the separation, purification, and other experimental methods and techniques for the solid organic compounds: refluxing, dropping, stirring, temperature controlling and cooling, crystallization, filtration, recrystallization, extraction, chromatographic separation.
Organic synthesis types:
1 Synthesis of macrocyclic compounds;
2 Synthesis of Heterocyclic Compounds;
3 Carbonyl condensation reaction;
4 The selective reaction or protection of the special functional groups, the concentration and additives on the reaction;
5 Redox reactions of specific functional groups;
6 The polymerization and molding.
D Experimental data Analysis and Interpretation, experimental report summary
1) Calculate the reaction conversion rate, product purity, ee % of chiral optically active compounds.
2) Data collection and analysis;: melting point (mp) of pure solid product, IR,UV , NMR, MS, X—Rays, AFM, the CD / ORD
3) by using the collected spectra data to determine the exact structure of the compounds;
4) Analysis: Reaction Mechanism, in particular the reasons for failure;
5) Experimental reports and the basic rules for the publication of the research |
| TextBooks: |
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| Reference: |
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1) Comprehensive chemical experiments, Zhejiang University, Nanjing University, Peking University, Lanzhou University, Higher Education Press, July 2001( 1st), 1 September 2006, 3rd printing.
2) http://www.orgsyn.org/
3) http://www.syntheticpages.com/ |
