| Name: |
NMR Principles and Applications |
| Catalog Number: |
412001Y |
Hours/Credits: |
40/2 |
| Prerequisite(s): |
|
Basic Organic Chemistry and Physical Chemistry |
| Course Description: |
|
With the development of science, technology and modern analytical techniques, NMR technology has become a workhorse in chemistry and medicine research, especially for the graduate students with research interests in organic chemistry and medicine research fields. NMR technique requires a strong theory background but has wide applications. This course covers the basic principles, concepts and terminology of nuclear magnetic resonance. Detailed experimental technique and spectrua interpretation will also be covered. The students will gain the abilities to analyze and resolve the problems during the NMR studies by taking the lecture, reading the literatures, discussing with others, and practicing with the computer-aided molecular modeling.
Successful completion of this course will allow the students to gain a fundamental understanding of the principles, the development, the instrumentation of NMR technique, and employ the technical terminology to fulfill their future scientific research in organic chemistry and medicine-related research. |
| Course Content: |
|
Chapter 1 Introduction
History of nuclear magnetic resonance, application of NMR in chemistry and medicine research
Chapter 2 Principles and Theories
Physical principles of NMR, nuclear spin, spin-spin coupling, chemical shift, nuclear shielding, ratios of the signal strength in NMR spectrum, relaxation time
Chapter 3 Modern NMR Techniques and Application
1D NMR technique, 2D NMR technique, homonuclear chemical shift - correlation spectroscopy, heteronuclear correlation spectroscopy, 2D NOE technique, 2D J-resolved spectroscopy, 2D spectra interpretation methods, selection of experimental parameters, resolution improvement with solvent suppression, sample preparation, NMR spectrum processing, variable-temperature NMR technique, multinuclear NMR, computer-aided molecular modeling, detection of medicine interaction and bimolecular interaction
Chapter 4 Interpretation of NMR Spectrum
Determine the structure of organic compounds, extensive interpretation of the structures of the complex chemical compounds, and conformation/configuration and stereochemical information of chemical compounds determined by NMR technique
Chapter 5 Seminar
Each student will be required to complete an oral presentation by analysis of primary literatures, or present the problems met in their research works, and discusses together with other students and the instructor. |
| TextBooks: |
|
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| Reference: |
|
1. Structure Determination of Organic Compounds and Spectral Analysis, edited by Ning, Y., Science Press, 2000
2. Principles and Interpretation of NMR, edited by Chang J, Dong Y., Science Press, 2006
3. Modern NMR Techniques and Applications, edited by Mao X., Scientific and Technical Documentation Press, 2000
4. NMR Techniques, edited by Qiu Z., Pei F., Science Press, 1989
5. Magnetic Resonance in Biomedical Applications, edited by Zhang J., Du Z., Science Press, 2003
6. Modern NMR Techniques for Chemistry Research, edited by A. E. Derome, Pergamon Press, 1987
7. One-Dimensional and Two-Dimensional NMR Spectra By Modern Pulse Techniques，edited by K. Nakanishi, University Science Books, 1990
8. NMR of Proteins and Nucleic Acids, edited by K. Wuthrich, Wiley-Interscience, 1986
9. 200 and More NMR Experiments, edited by S. Berger, S. Braun, Wiley-VCH, 2004 |
