| Name: |
Organic Structural Analysis |
| Catalog Number: |
411007Y |
Hours/Credits: |
40/2 |
| Prerequisite(s): |
|
Basic Knowledge of Organic Chemistry and Analytical Chemistry |
| Course Description: |
|
This course will introduce the principles, instruments and applications of several important physical analytical methods; discuss the relationship between the structures of organic compounds and the spectra.
By this course, students will learn the applications of various spectra techniques and basic spectra interpretation ability, grasp the basic spectra analysis methods, and further get the structures of organic compounds from the spectra. |
| Course Content: |
|
Chapter 1 UV-visible Spectra
Electromagnetic spectrum; Beer-Lambert law and measurement deviation; Molecular orbital and electronic transitions of organic compounds; Chromophores; Choice of Solvent; Woodward-Fieser rule；absorption of aromatic compounds; D-π-A type molecule; instrument; Visual detection; Diffuse reflectance spectra; Diode array detection
Chapter 2 IR Spectra
Selection rules; Characteristic group frequencies; FT-IR and ATR; instrument;
Principles of Raman spectroscopy; Comparison between Raman and IR spectra;
New developments in Raman spectroscopy
Chapter 3 NMR Spectra
Nuclear spin and resonance; Spin-spin coupling; Chemical shift; Development of NMR; 1H-chemical shift; Factors affecting the chemical shift; 1H-1H coupling constants; n+1 rule; Improving the NMR spectrum (changing the magnetic field; D-exchange; shift reagents); NOE; PFT-NMR; Movement of nuclear magnetization vector; 13C-chemical shift; Relaxation time; Introduction to solid-state NMR; Introduction to 2D-NMR and some cases
Chapter 4 Mass Spectra
Introduction and New developments in MS; Various ion production methods (EI; CI; FIB; MALDI; ESI); Various mass analyzers (Magnetic analyzers; Ion cyclotron resonance analyzers; Time-of-flight analyzers; Quadrupole analyzers; Ion-trap analyzers); Structural information from MS; GC/MS and LC/MS
Chapter 5 Combination of spectroscopic methods
General approach; the combined application of spectroscopic methods （simple worked examples and practical research projects) |
| TextBooks: |
|
1）Williams, D.; Fleming, I. Spectroscopic Methods in Organic Chemistry, 6th ed.; McGraw-Hill: New York, 2007.
2）Zhao, Y. Spectroscopic Identification of the Structure of Organic
Molecules, 2nd ed.; Science Press: Beijing, 2010. |
| Reference: |
|
Sivelstein, R. M., Spectrometic Identification of Organic Compounds, 7th Ed., John Wiley & Sons, New York, 2005 |
