Chemistry
Name: Chemical Biology
Catalog Number: 412070Y Hours/Credits: 40/2
Prerequisite(s):
General Chemistry; Analytical Chemistry; Organic Chemistry; Bioorganic Chemistry; Basic Biochemistry.
Course Description:
The course is a specialized core course for graduate students in department of chemistry and biology, who take life science and biomedicine as their research objects. Chemical biology has increasingly developed in recent years, owing to the combination of chemistry and biology. It covers almost every subdiscipline and combines traditional bioorganic chemistry, biochemistry, medicinal chemistry, crystal chemistry, wave spectrum and computer chemistry. Biologists apply themselves to demonstrating the process of life, while chemists are used to regulating this process with micromolecules. Although there are cultural and interest differences between chemists and biologists, they are now seeking common basis in order to understand, imitate and control nature world, especially the biosystem. Chemical Biology, as a cross-field front subject, has a wide research area. The main contents of this course are basic concept of chemistry and biology, proteomics and chemical genomics, biocatalysis and biosynthesis, molecular recognition and assembly, biomanipulation and biological system simulation, design and synthesis of new drugs, new techniques and methods of chemical biology, etc. Students are expected to master basic concepts, major research contents, techniques and methods of chemical biology, and have a good knowledge of the rapid development of chemical biology in recent years.
Course Content:
Chapter 1 Introduction Brief introduction of chemical biology; Basic concepts of chemical biology; The formation, advances and development tendency of chemical biology and its influence on other contributing discipline. Chapter 2 Basic concept of chemistry Brief introduction of basic theory and important concepts of chemistry (chemical bond, law of thermodynamics,etc); Developments, trend and challenge of traditional chemistry; Unsolved classic problems of life chemistry: Origin of life and chemical evolution; Origin of chiral biomolecules; The origin of the biological clock, senescence and anti-senescence, etc. Chapter 3 Basic concept of biology Basic theory and significant concepts: protein, nucleic acid, sugar, vitamin and coenzyme, biocatalyst, hormone, central dogma, cell and biomembrane, biological oxidation and metabolism, etc. Chapter 4 Proteomics and genomics The origin and correlation techniques (methods) of proteomics; The origin and correlation techniques (methods) of genomics. Chapter 5 Biological catalysis and synthetic biology Basic concepts of biological catalysis and synthetic biology; Directed evolution technology; Metabolic engineering; Combinatorial chemistry; Combinatorial biosynthesis. Chapter 6 Molecular recognition and assembly Some basic concepts and principles of supramolecular chemistry; Molecular recognition, molecular assembly and molecular self-assembly; Molecular transport and supramolecular catalytic (mimetic enzyme); Molecular and supramolecular device; Micromolecules’ recognition of biomacromolecules and the interaction between them. Chapter 7 Bio-regulation and biological system simulation Basic types of bio-regulation and their effect; The influence of allogenic chemical materials on biomolecules; Biological system simulation; Peptide analogues; Peptide nucleic acid (PNA); Nuclear localization signal peptide and its application. Chapter 8 Design and synthesis of drugs Brief introduction of medicinal chemistry; (Virtual) screening and molecular simulation of new drugs; Study of new drugs whose nature products are lead compounds; Labeling and Pharmacological research of drugs; Positioning and transmission of drugs in body; Synthesis and purification of asymmetric drugs; Combinatorial synthesis of drugs. Chapter 9 New techniques and methods of chemical biology Challenges faced by analytical techniques and methods in the study of chemical biology; Nano-biotechnology; Biochip technique; Biological NMR; Bio-MS; Biosensor; Single-molecule detection and single cell detection, etc.
TextBooks:
Reference:
1. Related papers and comprehensive references bibliography. 2. Zhang, L.H; Wang, M.X.; Advances of Chemical Biology, Chemical Industry Press, First Edition in 2005.